• Trends in aminopenicillins (AP) consumption in Russia
• First report of metallo-beta-lactamase production in P.aeruginosa strains isolated in defferent regions of Russia

Posters from 6^th European Congress of Chemotherapy and Infection (ECC),
(December 1-3, 2004, Palais des Congrès de Paris, Paris, France)

• Trends in aminopenicillins (AP) consumption in Russia

  Abramenko L.P., Bedenkov A.V., Denisova M.N., Gotovats S.G., Ishmukhametov A.A., Stratchounski L.S.

  Traditionally, in Russia oral ampicillin was prescribed more frequently than amoxicillin. For example, in 1998, the proportion of ampicillin and amoxicillin consumption was 96.6% and 3.4% (1.7 vs 0.06 DDD/1000 inhabitants/day), respectively.
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• First report of metallo-beta-lactamase production in P.aeruginosa strains isolated in defferent regions of Russia

  L. Stratchounski, V. Kretchikov, I. Edelshtein, I. Kozlova, M. Edelshtein

  Carbapenem antibiotics have been used as drugs of last resort for the treatment of severe infections caused by multi-drug resistant gram-negative pathogens. Carbapenems are stable to hydrolysis by many beta-lactameses (including ESBL and AmpC), but destroyed by metallo-beta-lactamases (MBLs). Resistance mediated by acquired MBLs is increasingly reported in Pseudomonas aeruginosa in Asia, Europe, USA and Brasil. By today four groups of acquired carbapenems-hydrolyzing metalloenzymes have been described in this species: IMP, VIM, SPM and GIM.
  This is the first study to determine the prevalence of MBL production in nosocomial strains of P.aeruginosa from various Russian hospitals.
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